References

1 Omoigui S. The biochemical origin of pain: the origin of all pain is inflammation and the inflammatory response. Part 2 of 3 - inflammatory profile of pain syndromes. Med Hypotheses. 2007;69(6):1169-78. Epub 2007 Aug 28. PubMed PMID: 17728071; PubMed Central PMCID: PMC2771434.
2 O Radmark, et al. 5-Lipoxygenase: regulation of expression and enzyme activity, Trends in Biochemical Sciences. July 2007(32)7: 332-341
3 https://www.sciencedirect.com/topics/neuroscience/lipoxygenase; accessed July 13, 2018
4 Omoigui S. The biochemical origin of pain: the origin of all pain is inflammation and the inflammatory response. Part 2 of 3 - inflammatory profile of pain syndromes. Med Hypotheses. 2007;69(6):1169-78. Epub 2007 Aug 28. PubMed PMID: 17728071; PubMed Central PMCID: PMC2771434.
5 J Sherman. Neutralize a Lethal Enzyme, Life Extension Magazine. 2011
6 https://www.webmd.com/osteoarthritis/guide/anti-inflammatory-drugs#1
7 Maroon JC, Bost JW, Maroon A. Natural anti-inflammatory agents for pain relief. Surgical Neurology International. 2010;1:80. doi:10.4103/2152-7806.73804.
8 A Carter, Everything you need to know about NSAIDs. Medical News Today, May 2017
9 C Sostres, et al. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2010 Apr;24(2):121-32. doi:10.1016/j.bpg.2009.11.005. Review. PubMed PMID: 20227026.
10 Burnett BP, Levy RM. 5-Lipoxygenase metabolic contributions to NSAID-induced organ toxicity. Adv Ther. 2012 Feb;29(2):79-98. doi: 10.1007/s12325-011-0100-7. Epub 2012 Feb 7. Review. PubMed PMID: 22351432.
11 N. Kimmatkar, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – A randomized double blind placebo controlled trial, Phytomedicine, 2003(10)1: 3-7 ISSN 0944-7113,
12 MJ Miller, et al. The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complement Altern Med. 2006 Apr 7;6:13. PubMed PMID: 16603065; PubMed Central PMCID: PMC1456997.
13 A Kapil et al, Anticomplementary activity of boswellic acids--an inhibitor of C3-convertase of the classical complement pathway, International Journal of Immunopharmacology, Oct 1992; 14(7): 1139-43
14 N. Kimmatkar, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – A randomized double blind placebo controlled trial, Phytomedicine, 2003(10)1: 3-7 ISSN 0944-7113,
15 N. Kimmatkar, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – A randomized double blind placebo controlled trial, Phytomedicine, 2003(10)1: 3-7 ISSN 0944-7113,
16 Amar A. Vishal, et al. A Double Blind, Randomized, Placebo Controlled Clinical Study Evaluates the Early Efficacy of Aflapin®(ApresFlex) in Subjects with Osteoarthritis of Knee. Int. J. Med. Sci. 2011, 8.
17 AB Kunnumakkara , et al. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. British Journal of Pharmacology. 2017;174(11):1325-1348. doi:10.1111/bph.13621.
18 JL Funk, et al. Anti-Arthritic Effects and Toxicity of the Essential Oils of Turmeric (Curcuma longa L.)Journal of agricultural and food chemistry. 2010;58(2):842-849. doi:10.1021/jf9027206.
19 DS Kalman, et al. Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint®) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trialNutrition Journal. 2008;7:3. doi:10.1186/1475-2891-7-3.
20 G Bruno, Herbal COX-2 Inhibitors, Smart Supplementation: Huntington College of Health Sciences Literature Education Series On Dietary Supplements; 2009
21 G Bruno, Herbal COX-2 Inhibitors, Smart Supplementation: Huntington College of Health Sciences Literature Education Series On Dietary Supplements; 2009
22 H Sumner, et al. Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew: Involvement of sesquiterpene lactones and other components, Biochemical Pharmacology, 1992 (43) 11: 2313-20, ISSN 0006-2952, https://doi.org/10.1016/0006-2952(92)90308-6.
23 Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr. 2000 Dec;3(4A):509-14. Review. PubMed PMID: 11276299.
24 Baikal Skullcap: Monograph, Natural Medicines Comprehensive Database; Updated 06/01/2018
1 http://subscriptions.bioethika.com/pdf/baikal_skullcap.pdf
25 J Piscoya, et al. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res. 2001 Sep;50(9):442-8. PubMed PMID: 11603848.
27 MJ Miller, et al. The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complement Altern Med. 2006 Apr 7;6:13. PubMed PMID: 16603065; PubMed Central PMCID: PMC1456997.
27 Yin K, Agrawal DK. Vitamin D and inflammatory diseasesJournal of Inflammation Research. 2014;7:69-87. doi:10.2147/JIR.S63898.
28 Pal CP, Kumar H, Kumar D, et al. Prevalence of vitamin D deficiency in orthopaedic patients – A single centre studyJournal of Clinical Orthopaedics and Trauma. 2016;7(Suppl 2):143-146. doi:10.1016/j.jcot.2016.06.009.
29 Al Faraj, et al. Vitamin D Deficiency and Chronic Low Back Pain in Saudi Arabia, Spine: Jan 2003(28) 2:177-179
30 N Begum, et al. Evaluation of in vitro anti-inflammatory and COX-2
31 inhibitory activity of leaves of Origanum vulgare, The Pharma Innovation Journal, 2016; 5(8): 18-21
32 http://www.bioperine.com/index.php/aboutbioperine

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